U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pancreas divisum

MedGen UID:
539810
•Concept ID:
C0266270
•
Congenital Abnormality
Synonyms: Divisum, Pancreas; Divisum, Pancreatic; Pancreas Divisum; Pancreas Divisums; Pancreatic Divisum; Pancreatic Divisums
SNOMED CT: Pancreatic divisum (54554009); Pancreas divisum (54554009)
 
HPO: HP:0030994

Definition

A congenital anomaly of the pancreas that results from failed fusion of the dorsal and ventral ducts during embyological development. Three variants have been described [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPancreas divisum

Professional guidelines

PubMed

AGA Clinical Practice Update on the Endoscopic Approach to Recurrent Acute and Chronic Pancreatitis: Expert Review.
Strand DS, Law RJ, Yang D, Elmunzer BJ
Gastroenterology 2022 Oct;163(4):1107-1114. Epub 2022 Aug 22 doi: 10.1053/j.gastro.2022.07.079. PMID: 36008176
Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Diagnosis and treatment of pancreas divisum: A literature review.
Ferri V, Vicente E, Quijano Y, Ielpo B, Duran H, Diaz E, Fabra I, Caruso R
Hepatobiliary Pancreat Dis Int 2019 Aug;18(4):332-336. Epub 2019 May 20 doi: 10.1016/j.hbpd.2019.05.004. PMID: 31155429

Recent clinical studies

Etiology

AGA Clinical Practice Update on the Endoscopic Approach to Recurrent Acute and Chronic Pancreatitis: Expert Review.
Strand DS, Law RJ, Yang D, Elmunzer BJ
Gastroenterology 2022 Oct;163(4):1107-1114. Epub 2022 Aug 22 doi: 10.1053/j.gastro.2022.07.079. PMID: 36008176
Pancreas divisum inversus.
Renzulli M, Pagano N, Golfieri R
Clin Anat 2020 Jul;33(5):646-652. Epub 2019 Oct 12 doi: 10.1002/ca.23475. PMID: 31576611
Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Pancreas Divisum.
Taj MA, Qureshi S, Ghazanfar S, Siddiqui AR, Niaz SK, Quraishy MS, Shahid M
J Coll Physicians Surg Pak 2016 Feb;26(2):96-9. PMID: 26876393
Acute recurrent pancreatitis.
Lehman GA
Can J Gastroenterol 2003 Jun;17(6):381-3. doi: 10.1155/2003/781237. PMID: 12813605

Diagnosis

AGA Clinical Practice Update on the Endoscopic Approach to Recurrent Acute and Chronic Pancreatitis: Expert Review.
Strand DS, Law RJ, Yang D, Elmunzer BJ
Gastroenterology 2022 Oct;163(4):1107-1114. Epub 2022 Aug 22 doi: 10.1053/j.gastro.2022.07.079. PMID: 36008176
Pancreas divisum inversus.
Renzulli M, Pagano N, Golfieri R
Clin Anat 2020 Jul;33(5):646-652. Epub 2019 Oct 12 doi: 10.1002/ca.23475. PMID: 31576611
Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Pancreas Divisum.
Taj MA, Qureshi S, Ghazanfar S, Siddiqui AR, Niaz SK, Quraishy MS, Shahid M
J Coll Physicians Surg Pak 2016 Feb;26(2):96-9. PMID: 26876393
Endoscopic ultrasound and pancreas divisum.
Rana SS, Gonen C, Vilmann P
JOP 2012 May 10;13(3):252-7. PMID: 22572127

Therapy

Endotherapy for Pancreas Divisum.
Inamdar S, Cote GA, Yadav D
Gastrointest Endosc Clin N Am 2023 Oct;33(4):789-805. Epub 2023 May 26 doi: 10.1016/j.giec.2023.04.012. PMID: 37709411
Pancreatic duct stents.
Yi JH, Li ZS, Hu LH
J Dig Dis 2022 Dec;23(12):675-686. Epub 2023 Mar 9 doi: 10.1111/1751-2980.13158. PMID: 36776138
AGA Clinical Practice Update on the Endoscopic Approach to Recurrent Acute and Chronic Pancreatitis: Expert Review.
Strand DS, Law RJ, Yang D, Elmunzer BJ
Gastroenterology 2022 Oct;163(4):1107-1114. Epub 2022 Aug 22 doi: 10.1053/j.gastro.2022.07.079. PMID: 36008176
Diagnosis and treatment of pancreas divisum: A literature review.
Ferri V, Vicente E, Quijano Y, Ielpo B, Duran H, Diaz E, Fabra I, Caruso R
Hepatobiliary Pancreat Dis Int 2019 Aug;18(4):332-336. Epub 2019 May 20 doi: 10.1016/j.hbpd.2019.05.004. PMID: 31155429
The Role of Endotherapy in Recurrent Acute Pancreatitis.
Guo A, Poneros JM
Gastrointest Endosc Clin N Am 2018 Oct;28(4):455-476. Epub 2018 Aug 1 doi: 10.1016/j.giec.2018.05.001. PMID: 30241638

Prognosis

AGA Clinical Practice Update on the Endoscopic Approach to Recurrent Acute and Chronic Pancreatitis: Expert Review.
Strand DS, Law RJ, Yang D, Elmunzer BJ
Gastroenterology 2022 Oct;163(4):1107-1114. Epub 2022 Aug 22 doi: 10.1053/j.gastro.2022.07.079. PMID: 36008176
Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Pancreas Divisum.
Taj MA, Qureshi S, Ghazanfar S, Siddiqui AR, Niaz SK, Quraishy MS, Shahid M
J Coll Physicians Surg Pak 2016 Feb;26(2):96-9. PMID: 26876393
Pancreas divisum.
DiMagno MJ, Wamsteker EJ
Curr Gastroenterol Rep 2011 Apr;13(2):150-6. doi: 10.1007/s11894-010-0170-8. PMID: 21222060Free PMC Article
Acute recurrent pancreatitis.
Lehman GA
Can J Gastroenterol 2003 Jun;17(6):381-3. doi: 10.1155/2003/781237. PMID: 12813605

Clinical prediction guides

Endotherapy for Pancreas Divisum.
Inamdar S, Cote GA, Yadav D
Gastrointest Endosc Clin N Am 2023 Oct;33(4):789-805. Epub 2023 May 26 doi: 10.1016/j.giec.2023.04.012. PMID: 37709411
AGA Clinical Practice Update on the Endoscopic Approach to Recurrent Acute and Chronic Pancreatitis: Expert Review.
Strand DS, Law RJ, Yang D, Elmunzer BJ
Gastroenterology 2022 Oct;163(4):1107-1114. Epub 2022 Aug 22 doi: 10.1053/j.gastro.2022.07.079. PMID: 36008176
Identification and management of pancreas divisum.
Gutta A, Fogel E, Sherman S
Expert Rev Gastroenterol Hepatol 2019 Nov;13(11):1089-1105. Epub 2019 Nov 8 doi: 10.1080/17474124.2019.1685871. PMID: 31663403Free PMC Article
Pancreas divisum.
DiMagno MJ, Wamsteker EJ
Curr Gastroenterol Rep 2011 Apr;13(2):150-6. doi: 10.1007/s11894-010-0170-8. PMID: 21222060Free PMC Article
Chronic pancreatitis.
DiMagno MJ, DiMagno EP
Curr Opin Gastroenterol 2005 Sep;21(5):544-54. doi: 10.1097/01.mog.0000175543.42582.55. PMID: 16093768

Recent systematic reviews

A systematic review and quantitative analysis of different therapies for pancreas divisum.
Hafezi M, Mayschak B, Probst P, Büchler MW, Hackert T, Mehrabi A
Am J Surg 2017 Sep;214(3):525-537. Epub 2017 Jan 3 doi: 10.1016/j.amjsurg.2016.12.025. PMID: 28110914
Endotherapy in symptomatic pancreas divisum: a systematic review.
Kanth R, Samji NS, Inaganti A, Komanapalli SD, Rivera R, Antillon MR, Roy PK
Pancreatology 2014 Jul-Aug;14(4):244-50. Epub 2014 Jun 11 doi: 10.1016/j.pan.2014.05.796. PMID: 25062871
Magnetic resonance cholangiopancreatography in the diagnosis of pancreas divisum: a systematic review and meta-analysis.
Rustagi T, Njei B
Pancreas 2014 Aug;43(6):823-8. doi: 10.1097/MPA.0000000000000143. PMID: 24743381
A systematic review on endoscopic detection rate, endotherapy, and surgery for pancreas divisum.
Liao Z, Gao R, Wang W, Ye Z, Lai XW, Wang XT, Hu LH, Li ZS
Endoscopy 2009 May;41(5):439-44. Epub 2009 Mar 31 doi: 10.1055/s-0029-1214505. PMID: 19337962
Acute idiopathic pancreatitis: does it really exist or is it a myth?
van Brummelen SE, Venneman NG, van Erpecum KJ, VanBerge-Henegouwen GP
Scand J Gastroenterol Suppl 2003;(239):117-22. doi: 10.1080/008559203100027. PMID: 14743894

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...